R&D SYNTHESIS

Striving for Innovation, this service of JDM Research is backed by a team of Professionals with expertise in Chemistry.

R & D Synthesis

Development of New Actives / Enantiomers
Crystal Structure / Polymorph Study
Process Optimization / Trouble Shooting
Process Validation
Purification (Fractional Distillation / Crystallization)
Standard Preparation (Active and its Impurities)

Capabilities

Hazardous Reaction - Cyanation, Grignard, etc.
Chlorination - using Cl2 gas, SOCl2, SO2Cl2, etc.
Bromination
Air Sensitive Reaction - using n-BuLi, LiAlH4, NaH, etc.
High Pressure Reaction
Hydrogenations (Raney Ni / Pd-C)
Diazotization, Oxidation, Reduction, Nitration, Sulfonation, Acetylation, Friedel-craft, Sandmeyer, Wittig, Hoffmann Reaction, Suzuki Coupling, etc.
Chiral Synthesis

Infrastructure

Fume Hoods (Bench top / Walk-in)
Autoclaves
Rotavapors
Low / High Temperature Reactions Facility
Vacuum Pumps
Flash Chromatography

R & D is supported by Analytical Research Laboratory

Analysis (Raw Materials / Intermediates / Finish Products)
Method Development & Method Validation
Impurity Isolation
HPLC (RI / UV / PDA), GC (FID / TCD), Preparative HPLC, UV-Visible Spectrophotometer, Melting Point, Moisture Analyser, KF Analyser, Potentiometer, etc.

What we can do for you

You have a medicinal chemistry route and need to make 100-250 g for GLP Tox studies
Develop robust route for Tox / Phase-1 Studies (Process Research)
Replace route improving uses of toxic or hard to handle reagents. Develop green environmental friendly chemistry
Substitute multiple chromatographic separations (significant loss in yields) with suitable crystallization / purification method
Develop a cost effective route for up scale to be competitive
Reduce the number of steps, or decrease the cycle time to release capacit
Impurity Profiling

Equipment

Buchi Rotavapor

CombiFlash

Hydrogenarator

Lyophilizer

Vaccum Dryer

Vacuum Pump